Cartilage & Joint Repair
Cell-based approaches to osteoarthritis, measured on durable functional gain rather than short-term pain scores.
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Pioneering breakthroughs.
Transforming lives.
One hundred and fifty active protocols across cell therapy, biomaterials, drug repurposing and clinical translation — reported openly, including the results that disappointed us.
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The Model
Three disciplines, one feedback loop
Our programme rests on three interlocking fields. A finding in any one of them reliably unlocks progress in the other two — which is why we refuse to separate them into competing departments.
- Cell biology tells us what makes a stem cell potent — self-renewal, lineage commitment, senescence, and the niche signals governing all three.
- Genomics tells us who is likely to respond and why, through expression signatures, methylation state and donor variability.
- Translational science turns both into something a clinician can actually administer, with a dose, a route and a measurable endpoint.
Focus Areas
Six programmes we believe can shift clinical practice
Chosen because the unmet need is real, the biology is tractable, and we can measure whether it worked.
Bone Regeneration
Scaffold-supported osteogenesis for non-union fractures and critical-size defects that will not heal alone.
Related papersImmunomodulation
How cellular products reset chronic inflammatory signalling — and how to measure that with something better than symptom diaries.
Related papersWound & Dermal Repair
Adipose-derived approaches to chronic non-healing wounds, diabetic ulceration and post-surgical scarring.
Related papersBiomaterials
Hydrogels and matrices engineered to give cells the structural cue they need to organise into real tissue.
Related papersPotency Assays
Reliable measures of biological activity — the field's most persistent and least glamorous methodological weakness.
Related papersNow Recruiting
Selected active studies
Recruitment status is reviewed monthly. Every protocol below is registered and ethics-approved.
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Autologous MSC therapy in early knee osteoarthritis
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Extracellular vesicle preparations for chronic wound healing
In progress
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Hydrogel scaffold optimisation for critical-size bone defects
Follow-up
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Five-year outcome registry for orthobiologic interventions
Propose a collaboration
We share protocols, harmonise endpoints and co-author openly with partner institutions.